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Indoleamine 2,3-dioxygenase Expression and Functional Activity in Dendritic Cells Exposed to Cholera Toxin

✍ Scribed by L. Slavica; M. Nurkkala-Karlsson; T. Karlson; M. Ingelsten; J. Nyström; K. Eriksson


Book ID
115085889
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
554 KB
Volume
76
Category
Article
ISSN
0300-9475

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## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC