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Indole-3-carbinol modulation of hepatic monooxygenases CYP1A1, CYP1A2 and FMO1 in guinea pig, mouse and rabbit

✍ Scribed by S. Katchamart; D.E. Williams

Book ID
117794218
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
403 KB
Volume
129
Category
Article
ISSN
1532-0456

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## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYP‐mediated mechanisms underlying age‐dependent differences in susceptibility to toxicity. We evaluated CYP expressi