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Indium-mediated reductive coupling of acyl cyanides: a convenient synthesis of 1,2-diketones
β Scribed by Heung Soo Baek; Sung Jae Lee; Byung Woo Yoo; Jae Jung Ko; Sung Hoon Kim*; Joong Hyup Kim
- Book ID
- 104210962
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 61 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The indium-mediated reductive coupling of acyl cyanides afforded the corresponding 1,2-diketones in moderate to good yields under neutral and mild conditions.
π SIMILAR VOLUMES
Conversion of acyl cyanides 1 into 1,2-diketones 2 has been achieved by the action of ytterbium iodide in dry tetrahydrofuran at room temperature, in high yields.
Indium-mediated coupling of bromoacetonitrile and 2-bromopropionitrile with a variety of aromatic acyl cyanides afforded the corresponding aromatic a-cyano ketones in moderate to good yields under mild and neutral conditions.