Indirect nuclear Overhauser enhancements through 19F have been determined for the three-spin systems 'H-I9F-'H and 1H-'9F-'3C by steady-state presaturation of the appropriate proton, and applied to the conformational analysis of 5-bromo-2-fluoro-4-nitroacetanilide. The 'H NOE difference spectra at 4
Indirect negative nuclear Overhauser effects: Observation and applications
β Scribed by John D. Mersh; Jeremy K. M. Sanders
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 233 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0749-1581
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β¦ Synopsis
Abstract
Direct positive and indirect negative NOEs can often be observed in the same molecule, providing a method for establishing otherwise inaccessible connectivities in complex spectra and an effective probe of conformation in solution.
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The behavior of methyl beta-xylobioside has been analysed by 1H-n.m.r. spectroscopy for solutions in water and methanol in the range - 15 degrees to 85 degrees. Experimental n.O.e. values did not change with temperature and solvent in contrast to the inter-glycosidic 3JC,H values. Experimental n.O.e
## Abstract Nuclear Overhauser effect difference experiments, together with difference decoupling and inversion recovery measurements, have allowed the complete assignment of the proton magnetic resonance spectrum of carboprostacyclin. The nuclear Overhauser effect measurements prove the __5E__ con