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Indicators of Tau pathology in organotypic brain slices of inducible transgenic mice

โœ Scribed by Lars Messing; Eva Maria Mandelkow

Book ID
118466503
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
42 KB
Volume
6
Category
Article
ISSN
1552-5260

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Protein tau, a major microtubule-binding protein in the brain, comprises six isoforms generated through alternative mRNA splicing. A dysfunctional form of mutant and normal tau is associated or implicated in the pathogenesis of several neurodegenerative disorders. The neuropathological hallmark of t