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Analysis of high-MR polymers of protein tau in the brain of transgenic mice overexpressing human tau4R

โœ Scribed by Reena Lasrado; Kurt K. Spittaels; Chris V. Haute; Kris Vandenzande; Fred V. Leuven


Book ID
117411911
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
185 KB
Volume
21
Category
Article
ISSN
0197-4580

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Protein tau, a major microtubule-binding protein in the brain, comprises six isoforms generated through alternative mRNA splicing. A dysfunctional form of mutant and normal tau is associated or implicated in the pathogenesis of several neurodegenerative disorders. The neuropathological hallmark of t