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Indian hedgehog: Its roles and regulation in endochondral bone development

✍ Scribed by Lick Pui Lai; Jane Mitchell

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
199 KB
Volume
96
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Normal endochondral bone development requires the coordination of chondrocyte proliferation and differentiation. Indian hedgehog (Ihh) is a morphogen produced by chondrocytes in the early stage of terminal differentiation and plays several key roles in this process. Ihh regulates growth of adjacent proliferative chondrocytes and can also regulate the rate of differentiation of chondrocytes indirectly through its stimulation of parathyroid hormone‐related protein (PTHrP). In this review, we focus on recent studies that have identified new functions of Ihh and how Ihh itself is being regulated. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.

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