A tale of two proteins: Differential rol
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Kimberly A. Brown; Jennifer A. Pietenpol; Harold L. Moses
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Article
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2007
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John Wiley and Sons
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English
⚖ 396 KB
## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno