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Unique and redundant roles of Smad3 in TGF-β–mediated regulation of long bone development in organ culture

✍ Scribed by Jesus Alvarez; Rosa Serra


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
644 KB
Volume
230
Category
Article
ISSN
1058-8388

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## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno