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Cyclopentylglycine (Cpg) is a competitive inhibitor of isoleucine uptake in E. coli [1] and also has been used in designing angiotensin II antagonists [2]. We exploited a commercially available chiral auxillary [3] to obtain Cpg. Thus, stereoselective alkylation of the enolate derived from benzyl (2
We report a general approach to the synthesis of Boc-protected 4-alkylprolines via asymmetric hydrogenation reactions. Starting from trans-4-hydroxyproline, the key unsaturated intermediates were obtained by Wittig-type reactions at the 4 position. The Crabtree catalyst (Ir[COD]PyPCy 3 PF 6 ) proved
Osteoprotegerin (OPG) and OPG ligand (L) have recently been identified as novel proteins that inhibit and stimulate, respectively, osteoclast formation. In this investigation, the authors examined the possibility that OPG would inhibit cancerinduced osteoclastogenesis and cancer growth in bone. An e
This study was conducted to gain insight into the factors that may be responsible for poorly differentiated aggressive tumors. ## BACKGROUND. Several recent reports have shown that the breast carcinoma mortality rate is approximately three times as high in African-American women compared with othe