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Independent segregation of NZB immune abnormalities in NZB X C58 recombinant inbred mice

✍ Scribed by Maureen H. Bocchieri; Anne Cooke; J. Bruce Smith; Martin Weigert; Roy J. Riblet

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 635 KB
Volume: 12
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830120417

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✦ Synopsis

Abstract

The study of NZB X C58 recombinant inbred mouse strains has revealed independent segregation of naturally occurring thymocytotoxic antibody and Coombs' anti‐erythrocyte autoantibody. The lack of concordance of either of these autoantibodies with known heavy and light chain markers suggests that the autoantibodies are produced as a result of regulatory gene defects rather than alterations of antibody structural genes. Further, lack of concordance of the various autoimmune traits with eachother or with H‐2 or virus expression suggests that the autoimmune phenotype is not the result of a single “autoimmunity” gene but rather the outcome of faulty regulation of a number of independently segregating genes.

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