Independent roles of Rho-GTPases in growth cone and axonal behavior
β Scribed by Thies, Edda ;Davenport, Roger W.
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 247 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3034
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## Abstract At the leading edge of a growing axon, the growth cone determines the path the axon takes and also plays a role in the formation of branches, decisions that are regulated by a complex array of chemical signals. Here, we used microfabrication technology to determine whether differences i
Hippocampal neurons exhibit periodically recurring growth cone-like structures, referred to as "waves," that emerge at the base of neurites and travel distally to the tip. As a wave nears the tip, the neurite undergoes retraction, and when it reaches the tip, the neurite undergoes a burst of growth.
Phosphorylation of GAP-43 (neurowas low in organelle-poor lamellae. However, levels in modulin) by protein kinase C (PKC) occurs at a single lamellae were elevated when they became motile. Consite, serine 41 . In vivo, phosphorylation is induced after versely, levels of phosphorylated GAP-43 were lo