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Independent regulation of skeletal growth by Ihh and IGF signaling

โœ Scribed by Fanxin Long; Kyu-Sang Joeng; Shouhong Xuan; Argiris Efstratiadis; Andrew P. McMahon

Book ID
116976079
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
602 KB
Volume
298
Category
Article
ISSN
0012-1606

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Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effec