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Skeletal Unloading Induces Resistance to Insulin-Like Growth Factor-I (IGF-I) by Inhibiting Activation of the IGF-I Signaling Pathways

✍ Scribed by Takeshi Sakata; Yongmei Wang; Bernard P Halloran; Hashem Z Elalieh; Jay Cao; Daniel D Bikle


Book ID
111485003
Publisher
American Society for Bone and Mineral Research
Year
2003
Tongue
English
Weight
228 KB
Volume
19
Category
Article
ISSN
0884-0431

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✍ Emily J. Foulstone; Kate A. Meadows; Jeff M.P. Holly; Claire E.H. Stewart πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 239 KB

## Abstract IGF‐I and IGF‐II are thought to be unique in their ability to promote muscle cell differentiation. Murine C2 myoblasts differentiate when placed into low serum media (LSM), accompanied by increased IGF‐II and IGF binding protein‐5 (IGFBP‐5) production. Addition of 20 ng/ml TNFΞ± on trans