Independent Origin of a βS-Globin Gene in a Caucasian with Sickle Cell Anemia
✍ Scribed by JOSEPH E. GOOTENBERG; CORINNE D. BOEHM; HAIG H. KAZAZIAN JR.
- Book ID
- 119863392
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 300 KB
- Volume
- 565
- Category
- Article
- ISSN
- 0890-6564
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To examine the effects of unusual or atypical -globin gene cluster haplotypes on the hematological features and Hb F levels of sickle cell anemia, we studied African Americans who had an atypical or Cameroon haplotype chromosome in association with a typical haplotype. We identified over 20 atypica
Sickle cell anemia and ␣-thalassemia have a heterogeneous distribution in Venezuela with a high frequency in the coastal area (sea level) and few cases in the mountains. Most of our population is an ethnic admixture of Europeans (Spaniards colonists), Africans (slaves), and Amerindians. The purpose