The product of the retinoblastoma gene ( R B I ) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RBI may exert its growth-suppressing activity by regulating the transcription of a variety of growthrelated genes, including FOS, MYC, and TGFB /.
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
β Scribed by Cao, Liang; Faha, Barbara; Dembski, Marlene; Tsai, Li-Huei; Harlow, Ed; Dyson, Nicholas
- Book ID
- 109779304
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 623 KB
- Volume
- 355
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/355176a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Several proteins with important roles in oncogenesis have been shown to regulate the function of the E2Fβ1 transcription factor, which is known to activate the expression of genes required for proliferation and apoptosis. Here we identify the MDMX oncoprotein as an E2Fβ1βbinding factor,
Previous studies indicated that DNA adducts formed by a carcinogenic diol epoxide, 7r,8t-dihydroxy-9t, 10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normally specific binding sites. It was suggested that a