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Independent and interrelated regulation of ornithine decarboxylase by calcium and cAMP in fetal rat osteoblasts

✍ Scribed by J.P.T.M. van Leeuwen; M.P. Bos; M.P.M. Herrmann-Erlee


Book ID
113236415
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
1020 KB
Volume
9
Category
Article
ISSN
0143-4160

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## Abstract Cyclic AMP (cAMP) causes growth arrest in G~1~ and induction of cAMP phosphodiesterase and decrease of ornithine decarboxylase in S49 mouse lymphoma cells. Dibutyryl cAMP treatment of partially synchronized cells causes similar changes in activities of both enzymes, regardless of positi

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The role of cAMP and calcium in the induction of ornithine decarboxylase (ODC, E.C.4.1 .I .I 7) activity in the osteogenic sarcoma cell line, UMR 106-01, was studied, with particular interest for parathyroid hormone (PTH). PTH and forskolin dose-dependently induced the ODC activity and the cAMP prod

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The effect of activation of protein kinase C on stimulation of ornithine decarboxylase (ODC) activity and cAMP production was studied in fetal rat osteoblasts. Both phorbol 1 Zmyristate, 1 :<-acetate (PMA), an activator of protein kinase C, and 4cr-phorb01, ineffective in activating protein kinase C