✦ LIBER ✦

Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor

✍ Scribed by Fludzinski, Pawel; Evrard, Deborah A.; Bloomquist, William E.; Lacefield, William B.; Pfeifer, William; Jones, Noel D.; Deeter, Jack B.; Cohen, Marlene L.

Book ID: 120005506
Publisher: American Chemical Society
Year: 1987
Tongue: English
Weight: 305 KB
Volume: 30
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00392a001

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Preclinical anxiolytic versus antipsycho

Preclinical anxiolytic versus antipsychotic profiles of the 5-HT3 antagonists ondansetron, zacopride, 3α-tropanyl-1H-indole-3-carboxylic acid ester, and 1αH, 3α, 5αH-tropan-3-yl-3,5-dichlorobenzoate

✍ Robert W. Dunn; William A. Carlezon Jr.; Roy Corbett 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 850 KB

Synthesis, conformational and pharmacolo

Synthesis, conformational and pharmacological study of new compounds as possible antagonists of the 5HT-3 receptor

✍ B. Whelan; I. Iriepa; E. Gálvez; A. Orjales; C. Berisa; A. Labeaga; A.G. García; 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 253 KB

Design, Synthesis, and Pharmacological E

Design, Synthesis, and Pharmacological Evaluation of Novel 2-(4-substituted piperazin-1-yl)1, 8 Naphthyridine 3-Carboxylic Acids as 5-HT 3 Receptor Antagonists for the Management of Depression

✍ Dhar, Arghya K.; Mahesh, Radhakrishnan; Jindal, Ankur; Devadoss, Thangaraj; Bhat 📂 Article 📅 2014 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

Synthesis and Biological Evaluation of N

Synthesis and Biological Evaluation of Novel 5,8-Disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT6 and H1 Receptors Antagonists

✍ Alexandre V. Ivachtchenko; Eugene B. Frolov; Oleg D. Mitkin; Volodymyr M. Kysil; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 426 KB 👁 1 views

Design, synthesis and structure–activity

Design, synthesis and structure–activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression

✍ Radhakrishnan Mahesh; Thangaraj Devadoss; Dilip Kumar Pandey; Shvetank Bhatt; Sh 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 213 KB

Agonist and antagonist actions of yohimb

Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2-adrenergic receptors (AR)s, serotonin (5-HT)1A, 5-HT1B, 5-HT1D and dopamine D2 and D3 receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states

✍ Mark J. Millan; Adrian Newman-Tancredi; Valérie Audinot; Didier Cussac; François 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB 👁 1 views

Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum