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Increasing the work requirements lowers the threshold of naloxone for reducing self-stimulation in the midbrain of rats

✍ Scribed by Charles H.K. West; Gerald J. Schaefer; Richard P. Michael

Book ID
113219286
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
579 KB
Volume
18
Category
Article
ISSN
0091-3057

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✍ Gerald J. Schaefer; Richard P. Michael πŸ“‚ Article πŸ“… 1981 πŸ› Springer 🌐 English βš– 731 KB

Rats were implanted with stimulating electrodes aimed either at the medial forebrain bundle-lateral hypothalamus (MFB-LH) or the midbrain-central gray (MID-GG), and were trained to lever-press for brain selfstimulation on a fixed ratio: 15 schedule of reinforcement. The dose-dependent effects of mor