Increased understanding of platinum anticancer chemistry

✍ Scribed by Reedijk, Jan

• Book ID: 118194765
• Publisher: International Union of Pure and Applied Chemistry
• Year: 2011
• Tongue: English
• Weight: 345 KB
• Volume: 83
• Category: Article
• ISSN: 0033-4545
• DOI: 10.1351/pac-con-10-11-03

✦ Synopsis

The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.