Encapsulation of platinum anticancer drugs by apoferritin
β Scribed by Yang, Zhen; Wang, Xiaoyong; Diao, Huajia; Zhang, Junfeng; Li, Hongyan; Sun, Hongzhe; Guo, Zijian
- Book ID
- 120328225
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 476 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/B705326F
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## Abstract PMLA nanoparticles with diameters of 150β250βnm are prepared, and their hydrolytic degradation is studied under physiological conditions. Degradation occurs by hydrolysis of the side chain methyl ester followed by cleavage of the mainβchain ester group with methanol and Lβmalic acid as
Platinum-based anticancer agents such as cisplatin and carboplatin are in widespread clinical use but associated with many side effects. Improving the delivery of cytotoxic platinum compounds may lead to reduced side effects and achieve greater efficacy at lower doses. Polymer-based therapeutics hav