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Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters

✍ Scribed by Katsumichi Iki; Toshifumi Tsujiuchi; Toshimitsu Majima; Hiroyuki Sakitani; Masahiro Tsutsumi; Makoto Takahama; Masatoshi Yoshimoto; Dai Nakae; Tsukasa Tsunoda; Yoichi Konishi


Book ID
117469132
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
69 KB
Volume
131
Category
Article
ISSN
0304-3835

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## Abstract Alteration of the __Fhit__ gene was investigated in pancreatic duct adenocarcinomas induced by __N__‐nitrosobis(2‐oxopropyl)amine (BOP) in Syrian golden hamsters. The animals received 70 mg/kg BOP, followed by repeated exposure to an augmentation pressure regimen consisting of a choline