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Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease

✍ Scribed by Weetman, J.; Wong, M.B.; Sharry, S.; Rcom-H’cheo-Gauthier, A.; Gai, W.P.; Meedeniya, A.; Pountney, D.L.


Book ID
122691208
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
614 KB
Volume
544
Category
Article
ISSN
0304-3940

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## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial