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Increased sensitivity to endotoxemia in the bile duct–ligated cirrhotic rat

✍ Scribed by David Harry; Radhi Anand; Stephen Holt; Susan Davies; Richard Marley; Bimbi Fernando; David Goodier; Kevin Moore

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
228 KB
Volume
30
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Sepsis is a common complication of cirrhosis with a high mortality. In this study, we have investigated some of the pathways that may be involved in tissue injury and death. Bile duct-ligated (BDL) cirrhotic and control rats were challenged with lipopolysaccharide (LPS). Sensitivity to LPS was markedly enhanced in the BDL group, and was associated with increased liver injury and mortality. There was a 5-fold constitutive activation of nuclear factor B (NFB) in the liver of BDL rat controls (P F .001), and this was activated further, but to a similar extent, in the liver of both sham and BDL rats after injection of LPS.

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