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Increased self-diffusion of brain water in normal aging

✍ Scribed by Peter Gideon; Carsten Thomsen; Ole Henriksen

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
454 KB
Volume
4
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

With magnetic resonance (MR) imaging, brain water self‐diffusion was measured in 17 healthy volunteers 22–76 (mean, 44.6) years old. The calculated values for the apparent diffusion coefficients (ADCs) ranged from 0.58 × 10^−9^ to 1.23 × 10^−9^ m^2^/sec in cerebral white matter. A significant correlation was found between the ADC in white matter and age (r =.7069, P <.01). The calculated values for ADC in cortical gray matter ranged from 1.06 × 10^−9^ to 1.72 × 10^−9^ m^2^/sec no correlation was found between ADCs in gray matter and age. The increased ADC in white matter may be caused by an increase in the extracellular volume due to age‐dependent neuronal degeneration or to changes in myelination. These findings have implications for future clinical investigations with diffusion MR imaging techniques in patients with neurologic diseases, and stress the importance of having an agematched group of healthy volunteers for comparison.

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