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Increased risk of mortality associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR)

✍ Scribed by B.T. Heijmans; J. Gussekloo; C. Kluft; S. Droog; A.M. Lagaay; D.L. Knook; R.G.J. Westendorp; P.E. Slagboom


Book ID
119438863
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
153 KB
Volume
144
Category
Article
ISSN
0021-9150

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## Communicated by Mark Paalman Severe deficiency of methylenetetrahydrofolate reductase (MTHFR) is the most common inborn error of folate metabolism. Patients are characterized by severe hyperhomocysteinemia, homocystinuria and a variety of neurological and vascular problems. Eighteen rare mutatio