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Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR)

✍ Scribed by Heijmans, Bastiaan T; Gussekloo, Jacobijn; Kluft, Cornelis; Droog, Simone; Lagaay, A Margot; Knook, Dick L; Westendorp, Rudi GJ; Slagboom, Eline P


Book ID
110024791
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
134 KB
Volume
7
Category
Article
ISSN
1018-4813

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## Communicated by Mark Paalman Severe deficiency of methylenetetrahydrofolate reductase (MTHFR) is the most common inborn error of folate metabolism. Patients are characterized by severe hyperhomocysteinemia, homocystinuria and a variety of neurological and vascular problems. Eighteen rare mutatio