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Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus

✍ Scribed by Almas Rehman; Jaffar Nourooz-Zadeh; Wenke Möller; Hans Tritschler; Paulo Pereira; Barry Halliwell

Book ID
117110658
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
98 KB
Volume
448
Category
Article
ISSN
0014-5793

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✍ Mohammad Taghi Goodarzi; Ali Akbar Navidi; Mohsen Rezaei; Hossein Babahmadi-Reza 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

## Abstract Diabetic hyperglycemia is associated with increased production of reactive oxygen species (ROS). ROS reacts with DNA resulting in various products, such as 8‐hydroxydeoxyguanosine (8‐OHdG), that excrete in urine owing to DNA repair processes. Urinary 8‐OHdG has been proposed as an indic