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INCREASED MIF SECRETION BY NEUROENDOCRINE DIFFERENTIATED LNCAP CELLS INDUCES PROLIFERATION AND SURVIVAL OF PROSTATE CANCER CELLS

✍ Scribed by Tawadros, Thomas; Zarkik, Yassine; Roger, Thierry; Calandra, Thierry; Haefliger, Jacques-Antoine; Jichlinski, Patrice

Book ID: 123095775
Publisher: Lippincott Williams and Wilkins
Year: 2008
Tongue: English
Weight: 133 KB
Volume: 179
Category: Article
ISSN: 0022-5347
DOI: 10.1016/S0022-5347(08)61241-0

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## Abstract Activation of PKCδ in androgen‐dependent LNCaP prostate cancer cells leads to apoptosis via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of LNCaP cells with phorbol 12‐myristate 13‐acetate (PMA) leads to a PKCδ‐mediated autocrine release of death fa