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INCREASED MIF SECRETION BY NEUROENDOCRINE DIFFERENTIATED LNCAP CELLS INDUCES PROLIFERATION AND SURVIVAL OF PROSTATE CANCER CELLS

✍ Scribed by T. Tawadros; T. Roger; T. Calandra; J.A. Haefliger; P. Jichlinski

Book ID: 119618745
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 69 KB
Volume: 7
Category: Article
ISSN: 1569-9056
DOI: 10.1016/s1569-9056(08)60410-8

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## Abstract Activation of PKCδ in androgen‐dependent LNCaP prostate cancer cells leads to apoptosis via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of LNCaP cells with phorbol 12‐myristate 13‐acetate (PMA) leads to a PKCδ‐mediated autocrine release of death fa