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Increased longevity in offspring of mothers with alzheimer's disease

โœ Scribed by Jeremy M. Silverman; James Schmeidler; Michal Schnaider-Beeri; Hillel T. Grossman; Xiaodong Luo; Rebecca West; Rachel C. Lally; Joy Y. Wang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
64 KB
Volume
147B
Category
Article
ISSN
1552-4841

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Recently, the neurotoxic amyloid โค-peptide was shown to up-regulate polyamine metabolism by increasing ornithine decarboxylase (ODC) activity and polyamine uptake by initiating free radical damage in Alzheimer's disease (AD). 1 Because of these findings, polyamines have been considered to play an im