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Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage

✍ Scribed by M.K. Sharief; M.A. Noori; M. Ciardi; A. Cirelli; E.J. Thompson


Book ID
119108477
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
599 KB
Volume
43
Category
Article
ISSN
0165-5728

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Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag