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Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis

✍ Scribed by M. A. Moreira; C. P. Tilbery; L. P. Monteiro; M. M. Teixeira; A. L. Teixeira

Book ID
109337420
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
97 KB
Volume
114
Category
Article
ISSN
0001-6314

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Nitric oxide synthase is present in the
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels
✍ Vittorio Calabrese; Giovanni Scapagnini; Agrippino Ravagna; Rita Bella; Roberta πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 196 KB πŸ‘ 2 views

Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag