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Increased helix and protein stability through the introduction of a new tertiary hydrogen bond

✍ Scribed by Ronald W Peterson; Eric M Nicholson; Roopa Thapar; Rachel E Klevit; J.Martin Scholtz

Book ID
115629157
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
429 KB
Volume
286
Category
Article
ISSN
0022-2836

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Design and synthesis of a new type of mo
Design and synthesis of a new type of modified nucleoside for triple helix-mediated adenine-thymine base pair recognition: Formation of hydrogen bonds to the far-side adenine
✍ Akiko Saito; Reiko Kuroda πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 208 KB

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of trip