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Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche

✍ Scribed by Lourdes Ibáñez; Maria Victoria Marcos; Neus Potau; Carlie White; Christopher E Aston; Selma Feldman Witchel


Book ID
119419838
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
88 KB
Volume
78
Category
Article
ISSN
1556-5653

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Since the insulin receptor substrate-1 (IRS-1) is the major substrate of the insulin receptor tyrosine kinase and has been shown to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a potential candidate for development of non-insulin-dependent diabetes m