Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a
β¦ LIBER β¦
Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma
β Scribed by Jeng-Wei Lu; Jan-Gowth Chang; Kun-Tu Yeh; Rong-Ming Chen; Jeffrey J. P. Tsai; Wei-Wen Su; Rouh-Mei Hu
- Book ID
- 113094836
- Publisher
- Springer Milan
- Year
- 2012
- Tongue
- Spanish
- Weight
- 618 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1699-048X
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## Abstract Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic methylation patterns. Most of the studies concerning DNMT1 expression in human cancers have been performed o