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Increased Expression of p53 Protein Correlates With the Extent of Myocyte Damage in Cardiac Allograft Rejection

✍ Scribed by Bernadette K. McLaren; Prasanna K. Venkatesh; Praphul Misra; Ping L. Zhang; Marjorie R. Fowler


Book ID
114898104
Publisher
Wiley (Blackwell Publishing)
Year
2008
Tongue
English
Weight
172 KB
Volume
14
Category
Article
ISSN
1527-5299

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5