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bcl-2 protein expression in endometrial carcinoma: the lack of correlation with p53

✍ Scribed by Roman Miturski; Andrzej Semczuk; Jacek Tomaszewski; Jerzy Jakowicki

Book ID: 117469176
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 456 KB
Volume: 133
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(98)00193-1

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Bcl-2 protein inhibits apoptosis, reduces the requirement for growth factors, and thereby extends the survival of cells. Recent findings of Bcl-2 in several solid tumors suggest that it might contribute to the genesis of some types of cancer. Over-expression of Bcl-2 might play a role in carcinogene