Increased erythrocyte and protein binding of codeine in patients with sickle cell disease
โ Scribed by Sumia S. Mohammed; Mary M. Christopher; Paulette Mehta; Amos Kedar; Samuel Gross; Hartmut Derendorf
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 718 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-3549
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The transfusion histories over a 33-month period of 50 patients with sickle cell disease were reviewed to determine the frequency of alloimmunization to red cell antigens following transfusion in these patients. There were 30 females and 20 males, aged 19--49 years. Eighteen (36%) were immunized of
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Variation in the level of fetal hemoglobin (HbF) accounts for much of the clinical heterogeneity observed in patients with sickle cell disease (SCD). The HbF level has emerged as an important prognostic factor in both sickle cell pain and mortality, and a % HbF of 10-20% has been suggested as a thre