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Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia

✍ Scribed by MISRA, D. K.; HUMPHREYS, STEWART R.; FRIEDKIN, MORRIS; GOLDIN, ABRAHAM; CRAWFORD, ELIZABETH J.

Book ID
109613455
Publisher
Nature Publishing Group
Year
1961
Tongue
English
Weight
447 KB
Volume
189
Category
Article
ISSN
0028-0836

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Dihydrofolate reductase activity and res
Dihydrofolate reductase activity and resistance to aminopterin in various species of Drosophila
✍ Silber, J. ;Coste, A. ;Bazin, C. ;Menn, A. Le 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 380 KB

The aim of our work was to compare the mechanisms of resistance to aminopterin, inhibitor of the dihydrofolate reductase enzyme, between different Drosophila species and those described for cultured cells. Moreover we compared the systematic species divisions based on morphological traits and those