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Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells


Book ID
115767539
Publisher
Elsevier Science
Year
1961
Tongue
English
Weight
277 KB
Volume
7
Category
Article
ISSN
0006-2952

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Reduced permeability in CHO cells as a m
✍ Dr. Victor Ling; Larry H. Thompson πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 1015 KB

## Abstract Colchicine resistant (CH^R^) lines of stable phenotype have been isolated from cultured Chinese hamster (CHO) cells. Successive single‐step selections for increasing resistance were performed by isolating resistant colonies at each step. Two complementary assays involving [^3^H] colchic