Increased detection of HPV 16 virus in invasive, but not in early cervical cancers

✍ Scribed by D. Labeit; W. Back; F. V. Weizsäcker; P. Hermann; F. Melchert; K. Leonard; S. Labeit

• Book ID: 102910202
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 824 KB
• Volume: 36
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890360210

✦ Synopsis

Abstract

Human papilloma virus type 16 (HPV 16) DNA is found in about 50% of cervical squamous cell carcinomas (SCCs), and this association has raised the possibility of a causal role for HPV 16 in cervical carcinogenesis. We have tested this hypothesis by assaying a series of biopsies (n = 119) ranging from normal mucosa to infiltrating SCC with the PCR‐technique for the presence of HPV 16 DNA. While HPV 16 DNA was detected in 50% of our cases with invasive SCC, the incidence of HPV 16‐positive samples was about 10% in all other biopsies ranging from normal mucosa t o cases of carcinoma in situ. HPV 16 therefore appears to be involved in late tumor promotion but not in early tumor development.