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Increased Deiodination of L-Thyroxine and L-Triiodothyronine by Liver Microsomes from Rats treated with Phenobarbital

✍ Scribed by SCHWARTZ, H. L.; KOZYREFF, V.; SURKS, M. I.; OPPENHEIMER, J. H.

Book ID: 109665724
Publisher: Nature Publishing Group
Year: 1969
Tongue: English
Weight: 228 KB
Volume: 221
Category: Article
ISSN: 0028-0836
DOI: 10.1038/2211262a0

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## Abstract We studied effects of temperature on the deiodinating enzymatic pathways governing hepatic production of 3,5,3′‐triiodo‐L‐thyronine (T~3~) from L‐thyroxine (T~4~) in rainbow trout. Kinetics of outer‐ring deiodination (ORD) and inner‐ring deiodination (IRD) of T~4~ and T~3~ were measured