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Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers

✍ Scribed by Archey, William B; McEachern, Kristen A; Robson, Mark; Offit, Kenneth; Vaziri, Susan AJ; Casey, Graham; Borg, Åke; Arrick, Bradley A


Book ID
110066999
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
207 KB
Volume
21
Category
Article
ISSN
0950-9232

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We and others have shown previously that retinoic acid (RA) selectively inhibits the growth of estrogen receptor (ER)-positive human breast carcinoma (HBC) cells and ER-negative cells are refractory to RA inhibition o f growth. The ER-negative cells inherently express lower levels of RARa and retino