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Increased Colorectal Cancer Incidence in Obligate Carriers of Heterozygous Mutations in MUTYH

✍ Scribed by Natalie Jones; Stefanie Vogt; Maartje Nielsen; Daria Christian; Petra A. Wark; Diana Eccles; Emma Edwards; D. Gareth Evans; Eamonn R. Maher; Hans F. Vasen; Frederik J. Hes; Stefan Aretz; Julian R. Sampson

Book ID
119760968
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
279 KB
Volume
137
Category
Article
ISSN
0016-5085

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## Abstract The __MutYH__ gene is an adenine‐specific DNA glycosylase that prevents G/T transversions. Germline mutation in this gene causes __MYH__‐associated polyposis (MAP) that predispose to hereditary colorectal cancer (CRC). This study describes for the first time the association of the __Mut