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Increased chromosome instability in patients with chronic pancreatitis

✍ Scribed by Cottliar, A; Morán, C; Gomez, J; Martinez, S; Chopita, N; Geldern, P; Landoni, N; Sosa, E; Fundia, A; Berredo, A; Boerr, L; Slavutsky, I

Book ID
122893579
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
172 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Abstract Pancreatic adenocarcinoma is a disease with high mortality for which chronic pancreatitis confers a markedly increased risk. We hypothesize that chromosome instability and genomic damage occur in pre‐neoplastic pancreatic ductal epithelium, and that this damage may be related to oxidati