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Fosfomycin increases chromosome instability in lymphocytes from Fanconi Anemia patients

✍ Scribed by Sousa, Rosa; Ponte, Filipa; Teixeira, Sara; Andrade, Lara; Gonçalves, Cristina; Barbot, José; Coutinho, Jorge; Carvalho, Félix; Porto, Beatriz

Book ID
122020006
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
680 KB
Volume
754
Category
Article
ISSN
1383-5718

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The distribution of chromosome breaks induced by the antitumor drug cis-diamine-dichloroplatinum (II) in lymphocyte cultures from Fanconi anemia patients was analyzed. Breakpoints occurred nonrandomly over an arbitrarily defined human karyotype of 319 bands. These bands were classified according to