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Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia

โœ Scribed by Nootchanat Mairuae; James R. Connor; Poonlarp Cheepsunthorn


Book ID
116773433
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
478 KB
Volume
500
Category
Article
ISSN
0304-3940

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Activated macrophages produce several matrix metalloproteinases (MMPs), a family of extracellular matrix (ECM)-degrading enzymes, during wound healing and in other inflammatory states. In response to brain injury, brain microglia become "activated," in a way similar to peripheral tissue macrophages,