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Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression

✍ Scribed by Hofmann, U B; Westphal, J R; Waas, E T; Zendman, A J W; Cornelissen, I M H A; Ruiter, D J; Muijen, G N P van


Book ID
110002543
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
387 KB
Volume
81
Category
Article
ISSN
0007-0920

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t