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Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

✍ Scribed by Andreana C. Leskovjan; Ariane Kretlow; Antonio Lanzirotti; Raul Barrea; Stefan Vogt; Lisa M. Miller


Book ID
119331788
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
841 KB
Volume
55
Category
Article
ISSN
1053-8119

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## Abstract ## Purpose To demonstrate an MRI method for directly visualizing amyloid‐β (AΞ²) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T~1ρ~ relaxation rate increases progressively with Alzheimer's disease (AD)‐related pathology in the tg mouse brain. ## Materials a