Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia
โ Scribed by Kini, A R; Kay, N E; Peterson, L C
- Book ID
- 110054602
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 187 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0887-6924
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In 82 patients with B-chronic lymphocytic leukemia, the correlations between the histopathologic bone marrow patterns (interstitial, nodular, mixed, and diffuse), serum immunoglobulin (Ig), and blood B-lymphocyte levels and T-lymphocyte levels have been analyzed. The most commonly lowered Ig class w
Using a sensitive immunohistochemical technique and a specific monoclonal antibody (RFD-3), follicular dendritic cells (FDC) have been demonstrated in a significant proportion (6/12) of bone marrow samples from patients with nodular marrow involvement of B-cell chronic lymphocytic leukemia (B-CLL).
The present work analyzes the clinicobiological and immunological characteristics - the latter hitherto unexplored - of the different bone marrow histopathological patterns of the B-cell chronic lymphocytic leukaemia (B-CLL). In addition, we studied whether any or some of these parameters were able